BOSTON and LONDON — November 11, 2025 — Leads & Copy — Centessa Pharmaceuticals plc (Nasdaq: CNTA) has announced the commencement of an underwritten public offering of American Depositary Shares (ADSs), each representing one ordinary share. All ADSs will be offered by Centessa.
Centessa intends to grant the underwriters a 30-day option to purchase up to an additional 15% of the ADSs offered in the public offering. The offering is subject to market and other conditions. There is no assurance as to whether or when the offering may be completed, or as to the actual size or terms of the offering.
Jefferies, Leerink Partners, Evercore ISI, and Guggenheim Securities are acting as joint book-running managers for the offering. Oppenheimer & Co., Truist Securities, and LifeSci Capital are acting as co-lead managers.
The ADSs are being offered pursuant to a registration statement on Form S-3 that was filed with the Securities and Exchange Commission (SEC) on September 11, 2024, and became automatically effective upon filing. A preliminary prospectus supplement and accompanying prospectus relating to the offering will be filed with the SEC and will be available on the SEC’s website at http://www.sec.gov.
Copies of the preliminary prospectus supplement and the accompanying prospectus relating to the offering, when available, may be obtained from:
- Jefferies LLC, Attention: Equity Syndicate Prospectus Department, 520 Madison Avenue, New York, NY 10022, or by telephone at (877) 821-7388, or by e-mail at Prospectus_Department@Jefferies.com;
- Leerink Partners LLC, Syndicate Department, 53 State Street, 40th Floor, Boston, MA 02109, telephone: (800) 808-7525 ext. 6105, email: syndicate@leerink.com;
- Evercore Group L.L.C., Attention: Equity Capital Markets, 55 East 52nd Street, 35th Floor, New York, NY 10055, telephone: (888) 474-0200, email: ecm.prospectus@evercore.com;
- Guggenheim Securities, LLC, Attention: Equity Syndicate Department, 330 Madison Avenue, 8th Floor, New York, NY 10017, telephone: at (212) 518-9544, or by emailing GSEquityProspectusDelivery@guggenheimpartners.com.
This press release does not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation, or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.
Centessa Pharmaceuticals plc is a clinical-stage pharmaceutical company with a mission to discover, develop, and deliver medicines that are transformational for patients. The company is pioneering a new class of potential therapies within its orexin receptor 2 (OX2R) agonist program for the treatment of excessive daytime sleepiness (EDS), impaired attention, cognitive deficits, fatigue, and other symptoms across neurological, neurodegenerative, and neuropsychiatric disorders.
This release contains forward-looking statements. Any statements that are not statements of historical fact may be deemed to be forward-looking statements, including those relating to Centessa’s expectations regarding the completion, timing, and size of the public offering and its expectations with respect to granting the underwriters a 30-day option to purchase additional ADSs. Any forward-looking statements in this release are based on current expectations, estimates, and projections only as of the date of this release and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements.
These risks and uncertainties related to completion of the proposed public offering on the anticipated terms, or at all, include, but are not limited to, market conditions and the satisfaction of customary closing conditions related to the proposed public offering. Risks concerning Centessa’s programs and operations are described in additional detail in its Annual Report on Form 10-K, Quarterly Reports on Form 10-Q, and other reports, which are on file with the U.S. Securities and Exchange Commission. Centessa explicitly disclaims any obligation to update any forward-looking statements except to the extent required by law.
Contact:
Kristen K. Sheppard, Esq.
SVP of Investor Relations
investors@centessa.com
Source: Centessa Pharmaceuticals
